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KMID : 0388120090180040158
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Journal of Korean Society for the Study of Obesity
2009 Volume.18 No. 4 p.158 ~ p.166
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Relationship between C-reactive protein, several adipokines and metabolic risk factors in Korean children
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Lee Hea-Jin
Yun Kyung-Eun
Park Hye-Soon
Kim Sun-Mee
Choi Kyung-Mook
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Abstract
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Background: C-reactive protein and adipokines are associated with obesity and insulin resistance. The relations between C-reactive protein, adipokines and metabolic risk factors have been extensively studied in adults, but there are no comparable data in pre-pubertal children. We investigated the associations between C-reactive protein, several adipokines and metabolic risk factors in pre-pubertal Korean children.
Method: A total of 324 pre-pubertal children (149 boys and 175 girls) aged 8-9 years were evaluated for height, weight, blood pressure and body mass index (BMI). The serum hs-CRP, adiponectin, TNF-α, vaspin, RBP4, fasting glucose, insulin, lipid profile were also measured. Overweight was defined as being at or above the 85th percentile of the gender-specific BMI for age in the 2007 Korean National Growth Chart.
Results: In boys, serum hs-CRP levels were correlated with BMI (r=0.339, P<0.001), waist circumference (r=0.356, P<0.001), systolic blood pressure (r=0.183, P<0.05), diastolic blood pressure (r=0.168, P<0.05), ALT (r=0.311, P<0.001), insulin (r=0.226, P<0.05) and HOMA-IR (r=0.199, P<0.05). In girls, serum hs-CRP levels were correlated with BMI (r=0.332, P<0.001), waist circumference (r=0.311, P<0.001), Triglycerides (r=0.177, P<0.05), HDL-C (r=-0.232, P<0.001), ALT (r=0.152, P<0.05), insulin (r=0.238, P<0.01), HOMA-IR (r=0.233, P<0.01). Serum adiponectin levels were negatively correlated with ALT and AST in boys and total cholesterol levels in girls, respectively. There was no correlation between serum TNF-α, vaspin, RBP4 levels and metabolic risk factors in boys. In girls, serum fasting glucose levels was negatively correlated with serum TNF-α levels, and positively correlated with serum vaspin levels. In multiple linear regression analysis, body mass index was best predictor of hs-CRP in boys and girls.
Conclusion: Serum hs-CRP was significantly associated with BMI, waist circumference and other metabolic risk factors in pre-pubertal children. Among these metabolic risk factors, BMI was the best predictor of hs-CRP concentration in both boys and girls. A larger study might be helpful to characterize the relationship between metabolic risk factors and inflammatory markers in this age group.
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KEYWORD
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C-reactive protein, adipokines, children, metabolic risk factors
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